Mazatlán hosted the Caribbean Series in 1978, and Puerto Rico's Indios de Mayagüez claimed the championship with a 5-1 record. Second place was tied among the remaining teams, with Mayagüez finishing as the most consistent club through the round-robin.
Champion: Indios de Mayagüez · Country: Puerto Rico · Host: Mazatlán, Mexico
It was the 1st Caribbean Series title for Indios de Mayagüez and the 8th for Puerto Rico, which has won 16 in all.
The 1977 edition was won by Tigres del Licey in Caracas. Navegantes del Magallanes took the 1979 title in San Juan.