Mazatlán hosted the Caribbean Series in 2021, and the Dominican Republic's Águilas Cibaeñas claimed the championship by defeating Puerto Rico's Criollos de Caguas 4-1 in the final. The victory added another title to Cibaeñas' celebrated record as one of the most successful clubs in the history of the tournament.
Champion: Águilas Cibaeñas · Country: Dominican Republic · Host: Mazatlán, Mexico
It was the 6th Caribbean Series title for Águilas Cibaeñas and the 21st for Dominican Republic, which has won 23 in all. Mazatlán hosted the tournament for the 6th time.
The 2020 edition was won by Toros del Este in San Juan. Caimanes de Barranquilla took the 2022 title in Santo Domingo.