Caracas welcomed the Caribbean Series for the first time in 1951, hosting what would become one of the tournament's most enduring relationships between a city and a competition. Venezuela's capital offered the event a new geography and a distinct baseball culture, one that had been growing steadily through its own winter circuit. The host nation's teams would not win this edition, however — it was Cuba's Habana that took the championship, adding another title to the island's early dominance of the Series. The details of this edition remain partially unverified, and no Most Valuable Player is on record. What can be said with confidence is that Habana's success continued a pattern of Cuban clubs collecting titles in the tournament's first years, a pattern that reflected both the organizational depth of Cuban winter baseball and the quality of players it attracted. The 1951 visit to Caracas also planted seeds for what would become, decades later, Venezuela's own emergence as a powerful force in Caribbean baseball.
Champion: Cangrejeros de Santurce · Country: Puerto Rico · Host: Caracas, Venezuela · Manager: James Clarkson
It was the 1st Caribbean Series title for Cangrejeros de Santurce and the 1st for Puerto Rico, which has won 16 in all.
The 1950 edition was won by Carta Vieja Yankees in San Juan. Leones del Habana took the 1952 title in Panama City.