Panama City hosted the Caribbean Series for the first time in 1952, bringing the tournament to a country that had already produced a champion two years earlier with Carta Vieja. The Central American setting did not, however, produce a local champion this time. Cuba's Habana repeated as Series champion, making it back-to-back titles for the Havana club and reinforcing the impression, still forming in those early years, that Cuban clubs possessed structural advantages that their regional rivals would struggle to overcome consistently. No MVP was officially designated for this edition, and the available records carry some degree of uncertainty. Even so, the back-to-back championships by Habana in 1951 and 1952 stood as one of the more notable stretches of sustained excellence in the tournament's young history. Panama City's debut as host also confirmed that the Series was genuinely rotating among the four founding nations, lending the competition a regional legitimacy that went beyond the Cuban-centric geography of its opening edition.
Champion: Leones del Habana · Country: Cuba · Host: Panama City, Panama
It was the 1st Caribbean Series title for Leones del Habana and the 2nd for Cuba, which has won 8 in all.
The 1951 edition was won by Cangrejeros de Santurce in Caracas. Cangrejeros de Santurce took the 1953 title in Havana.