Panama City hosted the Caribbean Series for the third time in 1960, and Cienfuegos of Cuba claimed the championship, giving the Cuban club its second title in the tournament after their 1956 victory. It was the last edition of the Series before the competition was suspended — a suspension that would last a full decade, from 1961 through 1969. The Cuban Revolution's reshaping of professional baseball on the island made the continued participation of Cuban clubs impossible within the existing structure of Caribbean winter leagues. No Most Valuable Player is on record for this edition, and some details remain unverified. With the knowledge of what followed, the 1960 Caribbean Series carries a particular historical weight — a tournament unaware that it was holding its final edition of an era. The competition would not return until 1970, when it reconvened in Caracas with a new structure and without Cuban participation. The founding cycle, twelve editions played across four countries between 1949 and 1960, had come to a close.
Champion: Elefantes de Cienfuegos · Country: Cuba · Host: Panama City, Panama
It was the 2nd Caribbean Series title for Elefantes de Cienfuegos and the 7th for Cuba, which has won 8 in all. Panama City hosted the tournament for the 2nd time.
The 1959 edition was won by Alacranes del Almendares in Caracas. Navegantes del Magallanes took the 1970 title in Caracas.