Santo Domingo hosted the Caribbean Series in 2000, and Puerto Rico's Cangrejeros de Santurce were flawless through the round-robin, going 6-0 to claim the championship. The Dominican Republic's Águilas Cibaeñas finished as runner-up, as Santurce's perfect record delivered another milestone title for one of the competition's most historic clubs.
Champion: Cangrejeros de Santurce · Country: Puerto Rico · Host: Santo Domingo, Dominican Republic
It was the 5th Caribbean Series title for Cangrejeros de Santurce and the 14th for Puerto Rico, which has won 16 in all. Santo Domingo hosted the tournament for the 6th time.
The 1999 edition was won by Tigres del Licey in San Juan. Águilas Cibaeñas took the 2001 title in Culiacán.