Mazatlán hosted the Caribbean Series in 2005, and Mexico's Venados de Mazatlán claimed the championship on home soil with a 5-1 record. Second place was tied among the remaining teams, as Venados gave the host city its first Series title.
Champion: Venados de Mazatlán · Country: Mexico · Host: Mazatlán, Mexico
It was the 1st Caribbean Series title for Venados de Mazatlán and the 5th for Mexico, which has won 10 in all. Mazatlán hosted the tournament for the 5th time.
The 2004 edition was won by Tigres del Licey in Santo Domingo. Leones del Caracas took the 2006 title in Valencia.