The 2006 Caribbean Series was held across two Venezuelan cities — Valencia and Maracay — and Venezuela's Leones del Caracas were perfect through the round-robin, going 6-0 to claim the championship. The Dominican Republic's Tigres del Licey finished as runner-up, as Caracas delivered a flawless tournament on home soil.
Champion: Leones del Caracas · Country: Venezuela · Host: Valencia, Venezuela · Manager: Luis Dorante · Record: 7-1
It was the 2nd Caribbean Series title for Leones del Caracas and the 6th for Venezuela, which has won 8 in all.
The 2005 edition was won by Venados de Mazatlán in Mazatlán. Águilas Cibaeñas took the 2007 title in Carolina.